Alt click on a node connection automatically disconnect it from the other nodes. And there is some nodes which can be easily summoned by pressing a key and clicking at the same time. Like B+click will place a branch, and S+click a sequence.
If you're willing to compile it, Aseprite is a great option as well.
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Check out the beta version of a new web-based 3D painting app called PaintCube created to work on almost any modern device. The tool lets users paint onto 3D models using familiar tools and features Photoshop-style layers to blend and mix textures. There is also a customizable material system to edit model’s shaders and you can export the finished textures for use in other tools or in Photoshop format for further editing.
PaintCube is rental-based ($7 per month or $50 per year). You can also test a free 14-day trial. Learn more here.