Alt click on a node connection automatically disconnect it from the other nodes. And there is some nodes which can be easily summoned by pressing a key and clicking at the same time. Like B+click will place a branch, and S+click a sequence.
If you're willing to compile it, Aseprite is a great option as well.
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Check out this behind the scenes video on the production of characters and props for Ghost in the Shell. The amazing team of artists at Weta Workshop talks about the creative process behind the latest cyberpunk film.
Here are some concept artworks from Maciej Kuciara, Ash Thorp, Nick Keller, Adam Middleton and Andrew Baker: