Alt click on a node connection automatically disconnect it from the other nodes. And there is some nodes which can be easily summoned by pressing a key and clicking at the same time. Like B+click will place a branch, and S+click a sequence.
If you're willing to compile it, Aseprite is a great option as well.
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MWC14: Innovation Unleashed (Jon Matonis, Bitcoin)
Executive Director & Board Member of Bitcoin, Jon Matonis, gives a talk on the rising popularity if this currency this during MWC14 event.