Alt click on a node connection automatically disconnect it from the other nodes. And there is some nodes which can be easily summoned by pressing a key and clicking at the same time. Like B+click will place a branch, and S+click a sequence.
If you're willing to compile it, Aseprite is a great option as well.
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The GDC team shared another awesome talk! Giant Squid Studios’ Matt Nava offers insight into the unique art style of Abzu, and the processes that he and the team at Giant Squid developed to create it.
Also, take a look at our exclusive interview with the same developer from Giant Squid about the production of the game, where we’ve discussed the choice of art style, the peculiar challenges of underwater gameplay and work with environment production.
GDC talks cover a range of developmental topics including game design, programming, audio, visual arts, business management, production, online games, and much more. The teams post a fresh GDC video every day, so make sure to subscribe to the channel.