VFX artist mikuru created a beautiful Hollow fissure effect from miHoYo's Zenless Zone Zero in After Effects, and you can make one too with their easy-to-follow tutorial.
All you need is to combine several particle layers, and your own little flowing blob is ready to be used in games and scenes.
After Effects is a powerful tool for creating 2D VFX. Some of them can even look 3D!